Prolactin stimulates precursor cells in the adult mouse hippocampus

Walker, Tara L., Vukovic, Jana, Koudijs, Margaretha M., Blackmore, Daniel G., Mackay, Eirinn W., Sykes, Alex M., Overall, Rupert W., Hamlin, Adam S. and Bartlett, Perry F. (2012) Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS One, 7 9 Article No. e44371: . doi:10.1371/journal.pone.0044371

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Author Walker, Tara L.
Vukovic, Jana
Koudijs, Margaretha M.
Blackmore, Daniel G.
Mackay, Eirinn W.
Sykes, Alex M.
Overall, Rupert W.
Hamlin, Adam S.
Bartlett, Perry F.
Title Prolactin stimulates precursor cells in the adult mouse hippocampus
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1371/journal.pone.0044371
Open Access Status DOI
Volume 7
Issue 9 Article No. e44371
Total pages 11
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor cells in the adult mouse hippocampus. Using an in vitro neurosphere assay, we found that the addition of exogenous PRL to primary adult hippocampal cells resulted in an approximate 50% increase in neurosphere number. In addition, direct infusion of PRL into the adult dentate gyrus also resulted in a significant increase in neurosphere number. Together these data indicate that exogenous PRL can increase hippocampal precursor numbers both in vitro and in vivo. Conversely, PRL null mice showed a significant reduction (approximately 80%) in the number of hippocampal-derived neurospheres. Interestingly, no deficit in precursor proliferation was observed in vivo, indicating that in this situation other niche factors can compensate for a loss in PRL. The PRL loss resulted in learning and memory deficits in the PRL null mice, as indicated by significant deficits in the standard behavioral tests requiring input from the hippocampus. This behavioral deficit was rescued by direct infusion of recombinant PRL into the hippocampus, indicating that a lack of PRL in the adult mouse hippocampus can be correlated with impaired learning and memory
Keyword Nneural stem cells
Maternal behavior
Cns Neurons
Neurogenesis
Proliferation
Mice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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