Serum 25-hydroxyvitamin D 3 and D 2 and non-clinical psychotic experiences in childhood

Tolppanen, Anna-Maija, Sayers, Adrian, Fraser, William D., Lewis, Glyn, Zammit, Stanley, McGrath, John and Lawlor, Debbie A. (2012) Serum 25-hydroxyvitamin D 3 and D 2 and non-clinical psychotic experiences in childhood. PLoS One, 7 7 Article No. e41575: . doi:10.1371/journal.pone.0041575


Author Tolppanen, Anna-Maija
Sayers, Adrian
Fraser, William D.
Lewis, Glyn
Zammit, Stanley
McGrath, John
Lawlor, Debbie A.
Title Serum 25-hydroxyvitamin D 3 and D 2 and non-clinical psychotic experiences in childhood
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-07
Sub-type Article (original research)
DOI 10.1371/journal.pone.0041575
Open Access Status DOI
Volume 7
Issue 7 Article No. e41575
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
Objective: Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D 3 and 25(OH)D 2, have similar associations with psychosis-related outcomes. Methods: We investigated the association between serum 25(OH)D 3 and 25(OH)D 2 concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D 3 and 25(OH)D 2 concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182). Results: Higher 25(OH)D 3 concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D 2 were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D 2 concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value. Conclusions: Our findings of an inverse association of 25(OH)D 3 with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes
Keyword Vitamin D deficiency
Alspac Birth Cohort
General Population
Mendelian Randomization
Community Sample
D Supplements
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
 
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