Peptides as therapeutics with enhanced bioactivity

Goodwin, D., Simerska, P. and Toth, I. (2012) Peptides as therapeutics with enhanced bioactivity. Current Medicinal Chemistry, 19 26: 4451-4461. doi:10.2174/092986712803251548

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Author Goodwin, D.
Simerska, P.
Toth, I.
Title Peptides as therapeutics with enhanced bioactivity
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
Publication date 2012-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/092986712803251548
Volume 19
Issue 26
Start page 4451
End page 4461
Total pages 11
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract The development of techniques for efficient peptide production renewed interest in peptides as therapeutics. Numerous modifications for improving stability, transport and affinity profiles now exist. Several new adjuvant and carrier systems have also been developed, enhancing the immunogenicity of peptides thus allowing their development as vaccines. This review describes the established and experimental approaches for manufacturing peptide drugs and highlights the techniques currently used for improving their drug like properties.
Keyword Peptide
Drug delivery
Peptide therapeutic
Peptide drug
Peptide synthesis
Clinical trials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 43 times in Scopus Article | Citations
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Created: Thu, 15 Nov 2012, 11:01:54 EST by System User on behalf of School of Chemistry & Molecular Biosciences