Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis

Yan, Jun, Liu, Jia, Lin, Clement Yihao, Australia and New Zealand Multiple Sclerorsis Genetics Consortium, Csurhes, Peter A., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2012) Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis. International Journal of Molecular Sciences, 13 10: 13667-13679.


Author Yan, Jun
Liu, Jia
Lin, Clement Yihao
Australia and New Zealand Multiple Sclerorsis Genetics Consortium
Csurhes, Peter A.
Pender, Michael P.
McCombe, Pamela A.
Greer, Judith M.
Title Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis
Journal name International Journal of Molecular Sciences  (ERA 2012 Listed)    (ERA 2010 Rank C)   Check publisher's open access policy
Publication date 2012
Sub-type Article
DOI 10.3390/ijms131013667
Volume number 13
Issue number 10
ISSN 1422-0067
Start page 13667
End page 13679
Total pages 13
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2013
Language eng
Formatted abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system. Although the exact pathogenesis of MS is unknown, it is generally considered to be an autoimmune disease, with numerous genetic and environmental factors determining disease susceptibility and severity. One important mediator of immune responses and inflammation is interleukin-6 (IL-6). Previously, elevated levels of IL-6 in mononuclear cells in blood and in brain tissue from MS patients have been reported. Various polymorphisms in the promoter region of the IL6 gene have also been linked with IL-6 protein levels. In MS, several small studies have investigated whether two IL6 promoter polymorphisms (−597 G>A and −174 G>C) correlate with MS susceptibility, but with varying results. In the present study, we analyzed these polymorphisms, together with an additional polymorphism (−572 G>C) in 279 healthy controls and 509 patients with MS. We found no significant differences between MS patients and healthy controls for the different −597 or −174 IL6 promoter alleles or genotypes. There was a slight reduction in the percentage of individuals with MS who carried a C allele at position −572, although this was not significant after correction for multiple comparisons. Interestingly, however, the −572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression.
Keyword Multiple sclerosis
Interleukin 6
Polymorphism
Allele
Genotype
Disease Progression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received: 2 August 2012; in revised form: 20 September 2012 / Accepted: 27 September 2012 / Published: 22 October 2012

 
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Created: Mon, 12 Nov 2012, 10:58:20 EST by Roheen Gill on behalf of UQ Centre for Clinical Research