Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone

Maamary, Peter G., Ben Zakour, Nouri L., Cole, Jason N., Hollands, Andrew, Aziz, Ramy K., Barnett, Timothy C., Cork, Amanda J., Henningham, Anna, Sanderson-Smith, Martina, McArthur, Jason D., Venturini, Carola, Gillen, Christine M., Kirk, Joshua K., Johnson, Dwight R., Taylor, William L., Kaplan, Edward L., Kotb, Malak, Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2012) Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB Journal, 26 11: 4675-4684. doi:10.1096/fj.12-212142

Author Maamary, Peter G.
Ben Zakour, Nouri L.
Cole, Jason N.
Hollands, Andrew
Aziz, Ramy K.
Barnett, Timothy C.
Cork, Amanda J.
Henningham, Anna
Sanderson-Smith, Martina
McArthur, Jason D.
Venturini, Carola
Gillen, Christine M.
Kirk, Joshua K.
Johnson, Dwight R.
Taylor, William L.
Kaplan, Edward L.
Kotb, Malak
Nizet, Victor
Beatson, Scott A.
Walker, Mark J.
Total Author Count Override 20
Title Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone
Journal name FASEB Journal   Check publisher's open access policy
ISSN 0892-6638
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1096/fj.12-212142
Open Access Status
Volume 26
Issue 11
Start page 4675
End page 4684
Total pages 10
Place of publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Collection year 2013
Language eng
Formatted abstract
The past 50 years has witnessed the emergence of new viral and bacterial pathogens with global effect on human health. The hyperinvasive group A Streptococcus (GAS) M1T1 clone, first detected in the mid-1980s in the United States, has since disseminated worldwide and remains a major cause of severe invasive human infections. Although much is understood regarding the capacity of this pathogen to cause disease, much less is known of the precise evolutionary events selecting for its emergence. We used high-throughput technologies to sequence a World Health Organization strain collection of serotype M1 GAS and reconstructed its phylogeny based on the analysis of core genome single-nucleotide polymorphisms. We demonstrate that acquisition of a 36-kb genome segment from serotype M12 GAS and the bacteriophage-encoded DNase Sda1 led to increased virulence of the M1T1 precursor and occurred relatively early in the molecular evolutionary history of this strain. The more recent acquisition of the phage-encoded superantigen SpeA is likely to have provided selection advantage for the global dissemination of the M1T1 clone. This study provides an exemplar for the evolution and emergence of virulent clones from microbial populations existing commensally or causing only superficial infection.
Keyword Streptococcus pyogenes
Virulence factors
Reemergent pathogens
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Research Communication

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 11 Nov 2012, 11:26:57 EST by Dr Scott Beatson on behalf of School of Chemistry & Molecular Biosciences