Metformin therapy in patients with chronic kidney disease

Duong, J. K., Roberts, D. M., Furlong, T. J., Kumar, S. S., Greenfield, J. R., Kirkpatrick, C. M., Graham, G. G., Williams, K. M. and Day, R. O. (2012) Metformin therapy in patients with chronic kidney disease. Diabetes Obesity and Metabolism, 14 10: 963-965. doi:10.1111/j.1463-1326.2012.01617.x


Author Duong, J. K.
Roberts, D. M.
Furlong, T. J.
Kumar, S. S.
Greenfield, J. R.
Kirkpatrick, C. M.
Graham, G. G.
Williams, K. M.
Day, R. O.
Title Metformin therapy in patients with chronic kidney disease
Journal name Diabetes Obesity and Metabolism   Check publisher's open access policy
ISSN 1462-8902
1463-1326
Publication date 2012-10
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1111/j.1463-1326.2012.01617.x
Volume 14
Issue 10
Start page 963
End page 965
Total pages 3
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Abstract Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis. This open-label observational study investigated metformin and lactate concentrations in patients with CKD (n = 22; creatinine clearances 15–40 ml/min) and in two dialysed patients. Patients were prescribed a range of metformin doses (250–2000 mg daily) and metformin concentrations were compared with data from healthy subjects (scaled to 1500 mg twice daily). A subset of patients (n = 7) was controlled on low doses of metformin (250 or 500 mg daily). No correlation between metformin and lactate concentrations was observed. Three patients had high lactate concentrations (>2.7 mmol/l) and two had high metformin concentrations (3–5 mg/l), but none had any symptoms of lactic acidosis. Reducing metformin dosage and monitoring metformin concentrations will allow the safe use of metformin in CKD, provided that renal function is stable.
Keyword Diabetic nephropathy
Metformin
Pharmacokinetics
Pharmacology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Non HERDC
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