Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults

Schnidrig, Silvia, Casaulta, Carmen, Schibler, Andreas and Riedel, Thomas (2013) Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults. European Journal of Applied Physiology, 113 3: 591-598.

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Author Schnidrig, Silvia
Casaulta, Carmen
Schibler, Andreas
Riedel, Thomas
Title Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults
Journal name European Journal of Applied Physiology  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2013-03
Sub-type Article
Year available 2012
DOI 10.1007/s00421-012-2469-7
Volume number 113
Issue number 3
ISSN 1439-6319; 1439-6327
Start page 591
End page 598
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Formatted abstract Our understanding of regional filling of the
lung and regional ventilation distribution is based on
studies using stepwise inhalation of radiolabelled tracer
gases, magnetic resonance imaging and positron emission
tomography. We aimed to investigate whether these differences
in ventilation distribution at different end-expiratory
levels (EELs) and tidal volumes (VTs) held also true
during tidal breathing. Electrical impedance tomography
(EIT) measurements were performed in ten healthy adults
in the right lateral position. Five different EELs with four
different VTs at each EEL were tested in random order,
resulting in 19 combinations. There were no measurements
for the combination of the highest EEL/highest VT. EEL
and VT were controlled by visual feedback based on airflow.
The fraction of ventilation directed to different slices
of the lung (VENTRL1-VENTRL8) and the rate of the
regional filling of each slice versus the total lung were
analysed. With increasing EEL but normal tidal volume,
ventilation was preferentially distributed to the dependent
lung and the filling of the right and left lung was more
homogeneous. With increasing VT and maintained normal
EEL (FRC), ventilation was preferentially distributed to the
dependent lung and regional filling became more inhomogeneous
(p\0.05). We could demonstrate that regional
and temporal ventilation distribution during tidal breathing
was highly influenced by EEL and VT.
Keyword Lung mechanics
Electrical impedance tomography
Regional filling
Breathing pattern
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 8 August 2012

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
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Created: Fri, 09 Nov 2012, 15:10:02 EST by Matthew Lamb on behalf of School of Medicine