A core metabolic enzyme mediates resistance to phosphine gas

Schlipalius, David I., Valmas, Nicholas, Tuck, Andrew G., Jagadeesan, Rajeswaran, Ma, Li, Kaur, Ramandeep, Goldinger, Anita, Anderson, Cameron, Kuang, Jujiao, Zuryn, Steven, Mau, Yosep S., Cheng, Qiang, Collins, Patrick J., Nayak, Manoj K., Schirra, Horst Joachim, Hilliard, Massimo A. and Ebert, Paul R. (2012) A core metabolic enzyme mediates resistance to phosphine gas. Science, 338 6108: 807-810. doi:10.1126/science.1224951

Author Schlipalius, David I.
Valmas, Nicholas
Tuck, Andrew G.
Jagadeesan, Rajeswaran
Ma, Li
Kaur, Ramandeep
Goldinger, Anita
Anderson, Cameron
Kuang, Jujiao
Zuryn, Steven
Mau, Yosep S.
Cheng, Qiang
Collins, Patrick J.
Nayak, Manoj K.
Schirra, Horst Joachim
Hilliard, Massimo A.
Ebert, Paul R.
Title A core metabolic enzyme mediates resistance to phosphine gas
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1126/science.1224951
Volume 338
Issue 6108
Start page 807
End page 810
Total pages 4
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Collection year 2013
Language eng
Formatted abstract
Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security.
Keyword Dominica F coleoptera
Lesser grain borer
Rhyzopertha dominica
Caenorhabditis elegans
Comparative toxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 09 Nov 2012, 14:16:50 EST by Gail Walter on behalf of School of Biological Sciences