Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid

Harriott-Smith, T. G. and Halliday, W. J. (1988) Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid. Clinical and Experimental Immunology, 72 1: 174-177.

Author Harriott-Smith, T. G.
Halliday, W. J.
Title Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid
Journal name Clinical and Experimental Immunology   Check publisher's open access policy
ISSN 0009-9104
1365-2249
Publication date 1988
Sub-type Article (original research)
Volume 72
Issue 1
Start page 174
End page 177
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Cis-urocanic acid (cis-UCA), produced from trans-UCA (a normal component of epidermis) by UV irradiation, suppressed cell-mediated immunological reactions in vivo and in vitro. It suppressed the development of contact hypersensitivity (CHS) when injected into mice, and it suppressed leucocyte adherence inhibition (LAI) reactions of previously sensitized lymphocytes exposed to antigen. Serum from mice injected with cis-UCA was also immunosuppressive in vitro. Normal murine spleen cells cultured with cis-UCA produced a non-dialysable factor which suppressed LAI reactivity. Trans-UCA was ineffectual in all of these systems. Both the ability of cis-UCA to induce an immunosuppressive serum factor and its ability to suppress CHS were abrogated by prior administration of cyclophosphamide, indicating that cis-UCA (normally from irradiated epidermis) stimulates T suppressor cells to produce the previously described suppressor factor in serum and the immunosuppression associated with short-term irradiation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Wed, 07 Nov 2012, 12:25:36 EST by Tammy Smith on behalf of School of Chemistry & Molecular Biosciences