Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization

Harriott-Smith, T. G. and Halliday, W. J. (1986) Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization. Immunology, 57 2: 207-211.

Author Harriott-Smith, T. G.
Halliday, W. J.
Title Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization
Journal name Immunology   Check publisher's open access policy
ISSN 0019-2805
1365-2567
Publication date 1986
Sub-type Article (original research)
Volume 57
Issue 2
Start page 207
End page 211
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract BALB/c mice subjected to a single dose of UV-B radiation showed suppressed contact hypersensitivity to trinitrochlorobenzene. The in vitro antigen reactivity of peritoneal cells from these mice was investigated using the leucocyte-adherence inhibition assay. These cells showed a high degree of reactivity with specific antigen. However, this reactivity, but not the reactivity of cells from non-irradiated sensitized mice, could be suppressed by serum from UV-treated sensitized mice. The suppressive effect of this serum could also be demonstrated on other syngeneic systems with unrelated antigens and was partially effective with allogeneic cells, indicating a lack of antigen specificity and genetic restriction. Suppressive properties were also found in serum taken from mice 3-5 days (but not at other times) after irradiation without subsequent sensitization.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Wed, 07 Nov 2012, 12:19:18 EST by Tammy Smith on behalf of School of Chemistry & Molecular Biosciences