Production of suppressor factors induced by ultraviolet irradiation or cis-urocanic acid requires Lyt2+ lymphocytes

Harriott-Smith, Tammy G. and Halliday, W. J. (1988) Production of suppressor factors induced by ultraviolet irradiation or cis-urocanic acid requires Lyt2+ lymphocytes. Immunology and Cell Biology, 66 4: 313-318. doi:10.1038/icb.1988.41


Author Harriott-Smith, Tammy G.
Halliday, W. J.
Title Production of suppressor factors induced by ultraviolet irradiation or cis-urocanic acid requires Lyt2+ lymphocytes
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 1988
Sub-type Article (original research)
DOI 10.1038/icb.1988.41
Volume 66
Issue 4
Start page 313
End page 318
Total pages 6
Place of publication London, United Kingdom
Publisher Nature
Language eng
Formatted abstract
Both ultraviolet (UV) irradiation and cis-urocanic acid (UCA) are reported to be associated with the suppression of contact hypersensitivity (CHS) and the induction of a soluble factor which suppresses leukocyte adherence inhibition (LAI) assays in vitro. The cellular origin of the suppressor factor (SF) has now been investigated in vivo and in vitro, using monoclonal antibodies against lymphocyte surface markers to deplete certain cell populations, namely T lymphocytes bearing the L3T4 (helper) and Lyt-2 (suppressor) markers. Depletion of Lyt-2+ cells from irradiated mice in vivo and from spleen cell cultures in vitro led to the elimination of detectable levels of SF. Depletion of L3T4+ cells had no such effect. Similarly, Lyt-2+ cells (but not L3T4+ cells) were shown to be necessary for the production of SF by normal spleen cells cultured with cis-UCA. These data suggest that the production of SF following UV irradiation may be related to the action of cis-UCA on Lyg-2+ lymphocytes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Wed, 07 Nov 2012, 12:05:31 EST by Tammy Smith on behalf of School of Chemistry & Molecular Biosciences