Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study

Ferrari, Alize J., Saha, Sukanta, McGrath, John J., Norman, Rosana, Baxter, Amanda, Vos, Eric Theo and Whiteford, Harvey (2012) Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study. Population Health Metrics, 10 16.1-16.7.


Author Ferrari, Alize J.
Saha, Sukanta
McGrath, John J.
Norman, Rosana
Baxter, Amanda
Vos, Eric Theo
Whiteford, Harvey
Title Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study
Journal name Population Health Metrics   Check publisher's open access policy
ISSN 1478-7954
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1186/1478-7954-10-16
Volume 10
Start page 16.1
End page 16.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Abstract A comprehensive revision of the Global Burden of Disease (GBD) study is expected to be completed in 2012. This study utilizes a broad range of improved methods for assessing burden, including closer attention to empirically derived estimates of disability. The aim of this paper is to describe how GBD health states were derived for schizophrenia and bipolar disorder. These will be used in deriving health state-specific disability estimates. A literature review was first conducted to settle on a parsimonious set of health states for schizophrenia and bipolar disorder. A second review was conducted to investigate the proportion of schizophrenia and bipolar disorder cases experiencing these health states. These were pooled using a quality-effects model to estimate the overall proportion of cases in each state. The two schizophrenia health states were acute (predominantly positive symptoms) and residual (predominantly negative symptoms). The three bipolar disorder health states were depressive, manic, and residual. Based on estimates from six studies, 63% (38%-82%) of schizophrenia cases were in an acute state and 37% (18%-62%) were in a residual state. Another six studies were identified from which 23% (10%-39%) of bipolar disorder cases were in a manic state, 27% (11%-47%) were in a depressive state, and 50% (30%-70%) were in a residual state. This literature review revealed salient gaps in the literature that need to be addressed in future research. The pooled estimates are indicative only and more data are required to generate more definitive estimates. That said, rather than deriving burden estimates that fail to capture the changes in disability within schizophrenia and bipolar disorder, the derived proportions and their wide uncertainty intervals will be used in deriving disability estimates.
Keyword Global Burden of Disease
Health states
Schizophrenia
Bipolar disorder
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 16

 
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Created: Wed, 07 Nov 2012, 11:37:25 EST by Debra McMurtrie on behalf of Queensland Brain Institute