Changes in the diagnosed incidence of early onset schizophrenia over four decades

Okkels, N., Vernal, D. L., Jensen, S. O., McGrath, John J. and Nielsen, R. E. (2013) Changes in the diagnosed incidence of early onset schizophrenia over four decades. Acta Psychiatrica Scandinavica, 127 1: 62-68. doi:10.1111/j.1600-0447.2012.01913.x


Author Okkels, N.
Vernal, D. L.
Jensen, S. O.
McGrath, John J.
Nielsen, R. E.
Title Changes in the diagnosed incidence of early onset schizophrenia over four decades
Journal name Acta Psychiatrica Scandinavica   Check publisher's open access policy
ISSN 1600-0447
0001-690X
Publication date 2013-01-20
Year available 2012
Sub-type Article (original research)
DOI 10.1111/j.1600-0447.2012.01913.x
Volume 127
Issue 1
Start page 62
End page 68
Total pages 7
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Formatted abstract
Objective: To explore changes in the diagnosed incidence of early onset schizophrenia (EOS) from 1971 to 2010.

Method: Examination of incidence rates of schizophrenia in patients under 18 years of age, using a nationwide, population-based, mental health register.

Results: The age-standardized incidence rate (IR) of EOS in the period 1971–2010 was 3.17 (95% CI: 3.16, 3.18) per 100 000 person years in the age group 0–18 years, and 9.10 (95% CI: 9.00, 9.21) in the age group 12–18 years. In the period 1971–1993, the age-standardized IR of EOS was 1.80 (95% CI: 1.79, 1.82) per 100 000 person years in the age group 0–18 years, and 5.02 (95% CI: 4.92, 5.11) in the age group 12–18 years. In the period 1994–2010, the age-standardized IR of EOS was 5.15 (95% CI: 5.10, 5.20) per 100 000 person years in the age group 0–18 years, and 15.73 (95% CI: 15.22, 16.22) in the age group 12–18 years. The IR was higher for males than females in the periods 1971–1993 and 1971–2010, but in the period 1994–2010 the IR was higher for females than males.

Conclusion:
In recent years, the diagnosed incidence of EOS has increased and the usual male excess has disappeared. The changes in IR could be a result of changes in the diagnostic system, increased awareness of early psychosis or a reflection of actual underlying incidence of the disorder.
Keyword Incidence
Schizophrenia
Epidemiology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Early View - Article first published online: 20 AUG 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 05 Nov 2012, 17:01:28 EST by Debra McMurtrie on behalf of Queensland Brain Institute