Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

Reyes, Stefanie, Fu, Yuhong, Double, Kay L., Cottam, Veronica, Thompson, Lachlan H., Kirik, Deniz, Paxinos, George, Watson, Charles, Cooper, Helen M. and Halliday, Glenda M. (2013) Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of Aging, 34 3: 873-886. doi:10.1016/j.neurobiolaging.2012.07.019

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Author Reyes, Stefanie
Fu, Yuhong
Double, Kay L.
Cottam, Veronica
Thompson, Lachlan H.
Kirik, Deniz
Paxinos, George
Watson, Charles
Cooper, Helen M.
Halliday, Glenda M.
Title Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 1558-1497
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2012.07.019
Open Access Status File (Author Post-print)
Volume 34
Issue 3
Start page 873
End page 886
Total pages 14
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2013
Language eng
Abstract Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the transcription factors pituitary homeobox 3 (Pitx3) and orthodenticle homeobox 2 (Otx2) and the trophic factor receptor deleted in colorectal cancer (DCC), but there is limited information on their expression and localization in adult humans. Pitx3, Otx2, and DCC were immunohistochemically localized in the upper brainstem of adult humans and mice and protein expression assessed using relative intensity measures and online microarray data. Pitx3 was present and highly expressed in most dopamine neurons. Surprisingly, in our elderly subjects no Otx2 immunoreactivity was detected in dopamine neurons, although Otx2 gene expression was found in younger cases. Enhanced DCC gene expression occurred in the substantia nigra, and higher amounts of DCC protein characterized vulnerable ventral nigral dopamine neurons. Our data show that, at the age when Parkinson's disease typically occurs, there are no significant differences in the expression of transcription factors in brainstem dopamine neurons, but those most vulnerable to Parkinson's disease rely more on the trophic factor receptor DCC than other brainstem dopamine neurons.
Keyword Deleted in colorectal cancer
Dopamine neurons
Orthodenticle homeobox 2
Substantia nigra
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Corrected Proof - online 27 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
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Created: Mon, 05 Nov 2012, 16:13:58 EST by Debra McMurtrie on behalf of Queensland Brain Institute