Argonaute proteins at a glance

Ender, Christine and Meister, Gunter (2010) Argonaute proteins at a glance. Journal of Cell Science, 123 11: 1819-1823. doi:10.1242/jcs.055210

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Author Ender, Christine
Meister, Gunter
Title Argonaute proteins at a glance
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
1477-9137
Publication date 2010-06-01
Sub-type Article (original research)
DOI 10.1242/jcs.055210
Open Access Status File (Publisher version)
Volume 123
Issue 11
Start page 1819
End page 1823
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Abstract Although a large portion of the human genome is actively transcribed into RNA, less than 2% encodes proteins. Most transcripts are non-coding RNAs (ncRNAs), which have various cellular functions. Small ncRNAs (or small RNAs) – ncRNAs that are characteristically ~20-35 nucleotides long – are required for the regulation of gene expression in many different organisms. Most small RNA species fall into one of the following three classes: microRNAs (miRNAs), short-interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs) (Carthew and Sontheimer, 2009). Although different small RNA classes have different bio genesis pathways and exert different functions, all of them must associate with a member of the Argonaute protein family for activity. This article and its accompanying poster provide an overview of the different classes of small RNAs and the manner in which they interact with Argonaute protein family members during small-RNA-guided gene silencing. In addition, we highlight recently uncovered structural features of Argonaute proteins that shed light on their mechanism of action.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 81 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 05 Nov 2012, 09:05:04 EST by Susan Allen on behalf of Institute for Molecular Bioscience