Modulation of emotional appraisal by false physiological feedback during fMRI

Gray, Marcus A., Harrison, Neil A., Wiens, Stefan and Critchley, Hugo D. (2007) Modulation of emotional appraisal by false physiological feedback during fMRI. PLoS One, 2 6: e546.1-e546.9. doi:10.1371/journal.pone.0000546

Author Gray, Marcus A.
Harrison, Neil A.
Wiens, Stefan
Critchley, Hugo D.
Title Modulation of emotional appraisal by false physiological feedback during fMRI
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1371/journal.pone.0000546
Open Access Status DOI
Volume 2
Issue 6
Start page e546.1
End page e546.9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background: James and Lange proposed that emotions are the perception of physiological reactions. Two-level theories of emotion extend this model to suggest that cognitive interpretations of physiological changes shape self-reported emotions. Correspondingly false physiological feedback of evoked or tonic bodily responses can alter emotional attributions. Moreover, anxiety states are proposed to arise from detection of mismatch between actual and anticipated states of physiological arousal. However, the neural underpinnings of these phenomena previously have not been examined.
Methodology/Principal Findings: We undertook a functional brain imaging (fMRI) experiment to investigate how both primary and second-order levels of physiological (viscerosensory) representation impact on the processing of external emotional cues. 12 participants were scanned while judging face stimuli during both exercise and non-exercise conditions in the context of true and false auditory feedback of tonic heart rate. We observed that the perceived emotional intensity/salience of neutral faces was enhanced by false feedback of increased heart rate. Regional changes in neural activity corresponding to this behavioural interaction were observed within included right anterior insula, bilateral mid insula, and amygdala. In addition, right anterior insula activity was enhanced during by asynchronous relative to synchronous cardiac feedback even with no change in perceived or actual heart rate suggesting this region serves as a comparator to detect physiological mismatches. Finally, BOLD activity within right anterior insula and amygdala predicted the corresponding changes in perceived intensity ratings at both a group and an individual level.
Conclusions/Significance: Our findings identify the neural substrates supporting behavioural effects of false physiological feedback, and highlight mechanisms that underlie subjective anxiety states, including the importance of the right anterior insula in guiding second-order “cognitive” representations of bodily arousal state.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 30 Oct 2012, 11:31:45 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging