Comparative pharmacokinetics and pharmacodynamics of tablet, suspension and paste formulations of atenolol in cats

Khor, K. H., Campbell, F. E., Charles, B. G., Norris, R. L. G., Greer, R. M., Rathbone, M. J. and Mills, P. C. (2012) Comparative pharmacokinetics and pharmacodynamics of tablet, suspension and paste formulations of atenolol in cats. Journal of Veterinary Pharmacology and Therapeutics, 35 5: 437-445. doi:10.1111/j.1365-2885.2011.01342.x


Author Khor, K. H.
Campbell, F. E.
Charles, B. G.
Norris, R. L. G.
Greer, R. M.
Rathbone, M. J.
Mills, P. C.
Title Comparative pharmacokinetics and pharmacodynamics of tablet, suspension and paste formulations of atenolol in cats
Journal name Journal of Veterinary Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0140-7783
1365-2885
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1111/j.1365-2885.2011.01342.x
Volume 35
Issue 5
Start page 437
End page 445
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Abstract This study compared the pharmacokinetic and pharmacodynamic profiles of an extemporaneously prepared (compounded) atenolol paste and suspension for oral administration, against the commercially available divided tablet in healthy cats. Eleven healthy cats (mean: age 4±0.4year, weight 5.0±0.7 kg) were dosed twice-daily with 12.5mg atenolol (tablet, paste or suspension) for 7days in a randomized cross-over design with a 7-day wash-out period. On day 7, an electrocardiogram was performed before and immediately after stress provocation (jugular venipuncture) at prestudy screening, and at 2, 6 and 12h after morning dosing. Systolic arterial blood pressure (BP) was assessed following the second electrocardiogram. Plasma was collected at prestudy screening, and at 1, 2, 6 and 12h to measure atenolol plasma concentrations. Mean atenolol dose was 2.5mg/kg (range: 2.1-3.3mg/kg). Stress-induced rise in heart rate was attenuated (P<0.05) at every time point compared to baseline for all formulations. Although the paste significantly attenuated stress-induced elevation in heart rate at all time points, the effect was not consistently equivalent to the tablet. The BP was not altered (P>0.05) at any time point by any formulation. In conclusion, there were no significant differences (P>0.05) in any of the pharmacokinetic parameters or pharmacodynamic profiles of the paste and suspension compared to the commercially available tablet.
Keyword Hypertrophic cardiomyopathy
Pharmacological properties
Palatability
Hypertension
Management
Efficacy
Delivery
Liquid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Pharmacy Publications
School of Veterinary Science Publications
 
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