Bioanalytical assessment of the formation of disinfection byproducts in a drinking water treatment plant

Neale, Peta A., Antony, Alice, Bartkow, Michael E., Farre, Maria Jose, Heitz, Anna, Kristiana, Ina, Tang, Janet Y. M. and Escher, Beate I. (2012) Bioanalytical assessment of the formation of disinfection byproducts in a drinking water treatment plant. Environmental Science and Technology, 46 18: 10317-10325. doi:10.1021/es302126t

Author Neale, Peta A.
Antony, Alice
Bartkow, Michael E.
Farre, Maria Jose
Heitz, Anna
Kristiana, Ina
Tang, Janet Y. M.
Escher, Beate I.
Title Bioanalytical assessment of the formation of disinfection byproducts in a drinking water treatment plant
Journal name Environmental Science and Technology   Check publisher's open access policy
ISSN 0013-936X
Publication date 2012-09-18
Sub-type Article (original research)
DOI 10.1021/es302126t
Volume 46
Issue 18
Start page 10317
End page 10325
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2013
Language eng
Formatted abstract
Disinfection of drinking water is the most successful measure to reduce water-borne diseases and protect health. However, disinfection byproducts (DBPs) formed from the reaction of disinfectants such as chlorine and monochloramine with organic matter may cause bladder cancer and other adverse health effects. In this study the formation of DBPs through a full-scale water treatment plant serving a metropolitan area in Australia was assessed using in vitro bioanalytical tools, as well as through quantification of halogen-specific adsorbable organic halogens (AOXs), characterization of organic matter, and analytical quantification of selected regulated and emerging DBPs. The water treatment train consisted of coagulation, sand filtration, chlorination, addition of lime and fluoride, storage, and chloramination. Nonspecific toxicity peaked midway through the treatment train after the chlorination and storage steps. The dissolved organic matter concentration decreased after the coagulation step and then essentially remained constant during the treatment train. Concentrations of AOXs increased upon initial chlorination and continued to increase through the plant, probably due to increased chlorine contact time. Most of the quantified DBPs followed a trend similar to that of AOXs, with maximum concentrations observed in the final treated water after chloramination. The mostly chlorinated and brominated DBPs formed during treatment also caused reactive toxicity to increase after chlorination. Both genotoxicity with and without metabolic activation and the induction of the oxidative stress response pathway showed the same pattern as the nonspecific toxicity, with a maximum activity midway through the treatment train. Although measured effects cannot be directly translated to adverse health outcomes, this study demonstrates the applicability of bioanalytical tools to investigate DBP formation in a drinking water treatment plant, despite bioassays and sample preparation not yet being optimized for volatile DBPs. As such, the bioassays are useful as monitoring tools as they provide sensitive responses even at low DBP levels.
Keyword Bladder cancer
Cell line
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 44 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 26 Oct 2012, 19:18:25 EST by System User on behalf of National Res Centre For Environmental Toxicology