Long-range transcriptional regulation of breast cancer genes

Betts, Joshua A., French, Juliet D., Brown, Melissa A. and Edwards, Stacey L. (2012) Long-range transcriptional regulation of breast cancer genes. Genes, Chromosomes and Cancer, 52 2: 113-125. doi:10.1002/gcc.22020


Author Betts, Joshua A.
French, Juliet D.
Brown, Melissa A.
Edwards, Stacey L.
Title Long-range transcriptional regulation of breast cancer genes
Journal name Genes, Chromosomes and Cancer   Check publisher's open access policy
ISSN 1045-2257
1098-2264
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1002/gcc.22020
Open Access Status
Volume 52
Issue 2
Start page 113
End page 125
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Abstract Breast cancer is a major health problem and understanding the genetic basis of this disease is crucial for predicting risk and developing effective targeted therapeutics. Several breast cancer predisposing genes have been identified, but mutations in the coding regions of these genes only accounts for a small proportion of risk. Research now suggests that combinations of multiple non-coding changes in breast cancer susceptibility genes, which cause moderate alterations in gene expression, will be responsible for the remaining inherited risk. These non-coding changes will include variants in proximal and distal transcriptional and post-transcriptional regulatory elements and may affect the levels and function of trans-acting factors, including proteins and RNAs, which act on these elements. Somatic changes in such elements and factors have also been associated with breast cancer progression. With the recent advent of techniques allowing the detection of long-range DNA interactions spanning the human genome, it has become increasingly clear that long-range regulatory elements constitute an important mechanism for gene regulation. Recent studies have identified several such elements that are important for regulating genes involved in breast cancer, raising the possibility that defects in these sequences may contribute to breast cancer predisposition and progression. In this review, we discuss the emerging functions of cis-regulatory elements and a subset of trans-acting factors in breast tumorigenesis. We also discuss some recent progress in our understanding of how dysregulation in these transcriptional components may contribute to breast cancer, and the potential implications for molecular diagnosis, prognosis prediction, and the treatment of this disease.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Early view article - Article first published online: 18 OCT 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 26 Oct 2012, 14:32:01 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences