Acute effects of nicotine administration during prospective memory, an event related fMRI study

Rusted, Jennifer, Ruest, Torsten and Gray, Marcus A. (2011) Acute effects of nicotine administration during prospective memory, an event related fMRI study. Neuropsychologia, 49 9: 2362-2368.


Author Rusted, Jennifer
Ruest, Torsten
Gray, Marcus A.
Title Acute effects of nicotine administration during prospective memory, an event related fMRI study
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2011.04.009
Volume 49
Issue 9
Start page 2362
End page 2368
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract We previously demonstrated that stimulating neuronal nicotinic acetylcholine receptors modulates prospective memory (PM), the ability to remember and implement a prior intention. Here we used fMRI to explore the neuronal correlates of acute nicotinic (1 mg) modulation during PM, employing a double blind, valence-matched placebo-controlled design, and a solely event-related analysis. Eight healthy adults completed on two occasions (1 week washout) a simple attentional task containing infrequent PM trials. PM activated bilateral parietal, prefrontal (BA10) and anterior cingulate, and deactivated genual cingulate and medial prefrontal regions. Further, acute nicotine administration decreased activity within a largely overlapping right parietal region. This data validates a purely event-related approach to exploring PM, and suggests procholinergic modulation of PM by parietal rather than BA10/frontal regions.
Keyword Prospective memory
BA10
Nicotine
Acute psychopharmacology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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