Use of electron microscopy to classify canine perivascular wall tumors

Palmieri, C., Avallone, G., Cimini, M., Roccabianca, P., Stefanello, D. and Della Salda, L. (2012) Use of electron microscopy to classify canine perivascular wall tumors. Veterinary Pathology, 50 2: 226-233. doi:10.1177/0300985812456213


Author Palmieri, C.
Avallone, G.
Cimini, M.
Roccabianca, P.
Stefanello, D.
Della Salda, L.
Title Use of electron microscopy to classify canine perivascular wall tumors
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
1544-2217
Publication date 2012
Sub-type Article (original research)
DOI 10.1177/0300985812456213
Open Access Status Not Open Access
Volume 50
Issue 2
Start page 226
End page 233
Total pages 8
Place of publication Thousand Oaks, CA United States
Publisher Sage Publications
Collection year 2013
Language eng
Formatted abstract
The histologic classification of canine perivascular wall tumors (PWTs) is controversial. Many PWTs are still classified as hemangiopericytomas (HEPs), and the distinction from peripheral nerve sheath tumors (PNSTs) is still under debate. A recent histologic classification of canine soft tissue sarcomas included most histologic types of PWT but omitted those that were termed undifferentiated. Twelve cases of undifferentiated canine PWTs were evaluated by transmission electron microscopy. The ultrastructural findings supported a perivascular wall origin for all cases with 4 categories of differentiation: myopericytic (n = 4), myofibroblastic (n = 1), fibroblastic (n = 2), and undifferentiated (n = 5). A PNST was considered unlikely in each case based on immunohistochemical expression of desmin and/or the lack of typical ultrastructural features, such as basal lamina. Electron microscopy was pivotal for the subclassification of canine PWTs, and the results support the hypothesis that canine PWTs represent a continuum paralleling the phenotypic plasticity of vascular mural cells. The hypothesis that a subgroup of PWTs could arise from a pluripotent mesenchymal perivascular wall cell was also considered and may explain the diverse differentiation of canine PWTs.
Keyword Dog
Electron Microscopy
Hemangiopericytoma
Immunohistochemistry
Myopericytoma
Skin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes 2012 Aug 3. [Epub ahead of print]

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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Created: Sun, 21 Oct 2012, 12:10:00 EST by Chiara Palmieri on behalf of School of Veterinary Science