Maternal adaptations and inheritance in the transgenerational programming of adult disease

Gallo, Linda A., Tran, Melanie, Master, Jordanna S., Moritz, Karen M. and Wlodek, Mary E. (2012) Maternal adaptations and inheritance in the transgenerational programming of adult disease. Cell and Tissue Research, 349 3: 863-880. doi:10.1007/s00441-012-1411-y


Author Gallo, Linda A.
Tran, Melanie
Master, Jordanna S.
Moritz, Karen M.
Wlodek, Mary E.
Title Maternal adaptations and inheritance in the transgenerational programming of adult disease
Journal name Cell and Tissue Research   Check publisher's open access policy
ISSN 0302-766X
1432-0878
Publication date 2012-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00441-012-1411-y
Open Access Status
Volume 349
Issue 3
Start page 863
End page 880
Total pages 18
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract Adverse exposures in utero have long been linked with an increased susceptibility to adult cardio-renal and metabolic diseases. Clear gender differences exist, whereby growth-restricted females, although exhibiting some phenotypic modifications, are often protected from overt disease outcomes. One of the greatest physiological challenges facing the female gender, however, is that of pregnancy; yet little research has focused on the outcomes associated with this, as a potential ‘second-hit’ for those who were small at birth. We review the limited evidence suggesting that pregnancy may unmask cardio-renal and metabolic disease states and the consequences for long-term maternal health in females who were born small. Additionally, a growing area of research in this programming field is in the transgenerational transmission of low birth weight and disease susceptibility. Pathways for transmission might include an abnormal adaptation to pregnancy by the growth-restricted mother and/or inheritance via the parental germline. Strategies to optimise the pregnancy environment and/or prevent the consequences of inheritance of programmed deficits and dysfunction are of critical importance for future generations.
Keyword Transgenerational
Developmental programming
Fetal growth restriction
Maternal pregnancy adaptations
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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