Cyclization of peptides by using selenolanthionine bridges

Dantas de Araujo, Aline, Mobli, Mehdi, King, Glenn F. and Alewood, Paul F. (2012) Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie International Edition, 51 41: 10298-10302. doi:10.1002/anie.201204229

Author Dantas de Araujo, Aline
Mobli, Mehdi
King, Glenn F.
Alewood, Paul F.
Title Cyclization of peptides by using selenolanthionine bridges
Journal name Angewandte Chemie International Edition   Check publisher's open access policy
ISSN 1433-7851
Publication date 2012-10-08
Sub-type Article (original research)
DOI 10.1002/anie.201204229
Volume 51
Issue 41
Start page 10298
End page 10302
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH and Co. KGaA
Collection year 2013
Language eng
Formatted abstract
Selenocysteine does the job: Lanthionine bridges are important structural elements in naturally occurring lantibiotics. They can be engineered into peptides to increase biological activity and metabolic stability. Macrocyclization of peptides by intramolecular thiolation of cysteine is often difficult but can be achieved by replacing cysteine with the more reactive isosteric selenocysteine amino acid.
Keyword lanthionines
Peptide cyclization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Wed, 17 Oct 2012, 10:51:26 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging