Combining compartmental and microvascular models in interpreting dynamic PET data

Munk, Ole Lajord, Keiding, Susanne and Bass, Ludvik (2012). Combining compartmental and microvascular models in interpreting dynamic PET data. In Susanne Keiding and Michael Sørensen (Ed.), Functional molecular imaging in hepatology (pp. 24-31) Sharjah, United Arab Emirates: Bentham Science Publishers. doi:10.2174/97816080529051120101

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Author Munk, Ole Lajord
Keiding, Susanne
Bass, Ludvik
Title of chapter Combining compartmental and microvascular models in interpreting dynamic PET data
Title of book Functional molecular imaging in hepatology
Place of Publication Sharjah, United Arab Emirates
Publisher Bentham Science Publishers
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.2174/97816080529051120101
ISBN 9781608052905
Editor Susanne Keiding
Michael Sørensen
Start page 24
End page 31
Total pages 7
Total chapters 15
Collection year 2013
Language eng
Abstract/Summary Measurement of hepatic blood perfusion and of the exchange of substances between blood and cells is a challenge. Long before the development of PET, multiple indicator data were analysed using models based on elaborate capillary theories. Today, PET is a unique modality that allows external quantitative measurements of the regional distribution of intravenously injected radiotracers and their metabolites in tissues, but dynamic PET data are analysed using less physiologically based schemes. The standard compartment model is an inlet equilibration model that does not naturally incorporate blood flow, and a single-uptake model that does not allow substances to re-enter the capillaries. These deficiencies lead to paradoxes when modelling fast blood-cell exchange. We have combined compartmental and capillary theory and developed microvascular models that account for blood flow and concentration gradients in capillaries. The microvascular models can be regarded as revisions of the input function which include more physiological realism and provide a superior description and interpretation of dynamic PET data when compared to the standard compartmental scheme.
Keyword PET kinetics
Blood flow
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: School of Mathematics and Physics
Official 2013 Collection
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Created: Tue, 16 Oct 2012, 16:19:39 EST by Kay Mackie on behalf of School of Mathematics & Physics