Stimuli-free auto-modulated material release from mesoporous nanocompartment films

Ji, Qingmin, Miyahara, Masahiko, Hill, Jonathan P., Acharya, Somobrata, Vinu, Ajayan, Yoon, Suk Bon, Yu, Jong-Sung, Sakamoto, Kazutami and Ariga, Katsuhiko (2008) Stimuli-free auto-modulated material release from mesoporous nanocompartment films. Journal of the American Chemical Society, 130 8: 2376-2377. doi:10.1021/ja076139s

Author Ji, Qingmin
Miyahara, Masahiko
Hill, Jonathan P.
Acharya, Somobrata
Vinu, Ajayan
Yoon, Suk Bon
Yu, Jong-Sung
Sakamoto, Kazutami
Ariga, Katsuhiko
Title Stimuli-free auto-modulated material release from mesoporous nanocompartment films
Journal name Journal of the American Chemical Society   Check publisher's open access policy
ISSN 0002-7863
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1021/ja076139s
Volume 130
Issue 8
Start page 2376
End page 2377
Total pages 2
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract Mesoporous nanocompartment films composed of silica particles and hollow silica capsules were prepared by the layer-by-layer (LbL) technique. The resulting mesoporous nanocompartment films possess special molecular encapsulation and release capabilities so that stimuli-free auto-modulated stepwise release of water or drug molecules was achieved through the mesopore channels of robust silica capsule containers embedded in the film. Stepwise release of water was reproducibly observed that originates in the non-equilibrated rates between evaporation of water from the mesopore channels to the exterior and the capillary penetration of water from container interior to the mesopore channels. It was generalized to evaporation of other substances, fragrances, limonene. Application was also tested in the controlled release of the sunscreen UV-absorber (UV-S1) for circumvention of its rapid dissolution in water and prolongation of its prophylactic effect toward harmful ultraviolet radiation. UV-S1 was successfully entrapped within the mesoporous nanocompartment films and was released in a prolonged stepwise mode. The nanocompartment films developed in this research are promising materials for drug delivery since they allow gradual release of therapeutic agents with likely related improvements in their efficacy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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