The adsorption of the vitamin E (α-tocopherol) onto pure-silica and aluminum-containing C12-MCM-41, C16-MCM-41 and SBA-15 molecular sieves has been studied and the results are compared with those of amorphous silica. The influence of structure type, pore volume and composition of the adsorbent are investigated in detail. Moreover, different solvents such as n-heptane, cyclohexane, n-butanol and ethanol were studied. The vitamin E adsorption capacities depend on the solvent used as well as the specific surface area and the specific pore volume of the adsorbent. C16-MCM-41 shows the highest adsorption capacity as compared to other silica materials. The adsorption from n-heptane is significantly higher compared to those from the non-polar solvent cyclohexane and polar solvents such as n-butanol and ethanol. The adsorbent SBA-15 was characterized after vitamin E adsorption in order to confirm the structure of the adsorbent and the presence of vitamin E within the pores.