Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes

Ananthi, Nallamuthu, Balakrishnan, Umesh, Vinu, Ajayan, Ariga, Katsuhiko and Velmathi, Sivan (2009) Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes. Tetrahedron-Asymmetry, 20 15: 1731-1735. doi:10.1016/j.tetasy.2009.07.011


Author Ananthi, Nallamuthu
Balakrishnan, Umesh
Vinu, Ajayan
Ariga, Katsuhiko
Velmathi, Sivan
Title Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes
Journal name Tetrahedron-Asymmetry   Check publisher's open access policy
ISSN 0957-4166
1362-511X
Publication date 2009-08-01
Sub-type Article (original research)
DOI 10.1016/j.tetasy.2009.07.011
Volume 20
Issue 15
Start page 1731
End page 1735
Total pages 5
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
Chiral amide synthesized from (1S,2R)-(+)-norephedrine and furoic acid was found to catalyze the enantioselective ethylation of aromatic and heteroaromatic aldehydes to secondary alcohols with 99.8% enantioselectivity at 0 °C without the addition of a promoter such as titanium tetraisopropoxide.
Keyword Chiral amide
Enantioselective ethylation
Aldehydes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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