Highly efficient Friedel-crafts alkylation of indoles and pyrrole catalyzed by mesoporous 3D aluminosilicate catalyst with electron-deficient olefins

Naidu, T. Siddulu, Balasubramanian, V. V., Chari, M. A., Mori, T., Zaidi, S. M. J., Al-Deyab, Salem S., Reddy, B. V. Subba and Vinu, A. (2010) Highly efficient Friedel-crafts alkylation of indoles and pyrrole catalyzed by mesoporous 3D aluminosilicate catalyst with electron-deficient olefins. Synlett, 18: 2813-2817. doi:10.1055/s-0030-1258801


Author Naidu, T. Siddulu
Balasubramanian, V. V.
Chari, M. A.
Mori, T.
Zaidi, S. M. J.
Al-Deyab, Salem S.
Reddy, B. V. Subba
Vinu, A.
Title Highly efficient Friedel-crafts alkylation of indoles and pyrrole catalyzed by mesoporous 3D aluminosilicate catalyst with electron-deficient olefins
Journal name Synlett   Check publisher's open access policy
ISSN 0936-5214
1437-2096
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1055/s-0030-1258801
Issue 18
Start page 2813
End page 2817
Total pages 5
Place of publication Stuttgart, Germany
Publisher Georg Thieme Verlag
Language eng
Abstract The C3-selective Friedel-Crafts alkylation of indoles with electron-deficient olefins has been achieved using a mesoporous aluminosilicate catalyst with 3D cage-type porous structure to furnish the 3-alkylindole derivatives in excellent yields due to its high surface area, large pore volume and high acidity. Pyrrole also reacted efficiently under similar reaction conditions to give the corresponding 2-alkylated pyrrole derivatives in good yields.
Keyword Nanoporous aluminosilicate
Conjugate addition
Electron-deficient olefins
C3-alkylation of indoles
C2-alkylation of pyrrole
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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