Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems

Kapoor, Mahendra P., Vinu, Ajayan, Fujii, Wataru, Kimura, Tatsuo, Yang, Qihua, Kasama, Yuuki, Yanagi, Masaaki and Juneja, Lekh R. (2010) Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems. Microporous and Mesoporous Materials, 128 1-3: 187-193. doi:10.1016/j.micromeso.2009.08.019


Author Kapoor, Mahendra P.
Vinu, Ajayan
Fujii, Wataru
Kimura, Tatsuo
Yang, Qihua
Kasama, Yuuki
Yanagi, Masaaki
Juneja, Lekh R.
Title Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems
Journal name Microporous and Mesoporous Materials   Check publisher's open access policy
ISSN 1387-1811
1873-3093
Publication date 2010-03-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.micromeso.2009.08.019
Volume 128
Issue 1-3
Start page 187
End page 193
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Randomly ordered mesoporous silicas hollow microspheres of 20–50 μm in diameter with distinguished characteristic of interconnected porosity (7–14 nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a swelling agent, which was necessary for the formation of silica doped micelles to improve the mesoporous channel orientation without leading the phase transition. The interconnected pore channels that extend from the outside of the microspheres shell to its inside are used to fill the mesoporous silicas microspheres for enhanced encapsulation of VB3 precursor and cumulative in vitro release of vitamin B3 with considerable rate pharmacokinetics using simple pH trigger mechanism for the delivery systems.
Keyword Self-assembly
Hollow microspheres
Emulsifiers
Food grade
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online 22 August 2009

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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