The association between lower birth weight and comorbid generalised anxiety and major depressive disorder

Betts, Kim Steven, Williams, Gail M., Najman, Jacob M., Scott, James and Alati, Rosa (2013) The association between lower birth weight and comorbid generalised anxiety and major depressive disorder. Journal of Affective Disorders, 146 2: 231-237.

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Author Betts, Kim Steven
Williams, Gail M.
Najman, Jacob M.
Scott, James
Alati, Rosa
Title The association between lower birth weight and comorbid generalised anxiety and major depressive disorder
Journal name Journal of Affective Disorders   Check publisher's open access policy
ISSN 0165-0327
1573-2517
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.jad.2012.09.010
Volume 146
Issue 2
Start page 231
End page 237
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract Objective: Studies testing the association between birth weight and depression or anxiety have found inconsistent results and there has been a lack of research on the possible relationship between birth weight and comorbid anxiety and depression. We tested for an association between lower birth weight and major depression, generalised anxiety and comorbid generalised anxiety and major depression.
Method: Data was taken from 2113 mothers and their offspring participating in the Mater University Study of Pregnancy (MUSP) birth cohort. Generalised anxiety, major depression and comorbid generalised anxiety and major depression at 21 years were tested for associations with birth weight using multinomial logistic regression.
Results: Lower birth weight was found to predict comorbid generalised anxiety and major depression, but did not predict either generalised anxiety or major depression.
Limitations: We were unable to specify comorbidity by the primary disorder, or by the severity or recurrence of the depression.
Conclusion: Previous associations found between birth weight and mental health may reflect a specific link between lower birth weight and comorbid generalised anxiety and major depressive disorders. As neither disorder individually was associated with lower birth weight, this may suggest that this developmental origin represents a unique risk pathway to comorbidity not shared with either discrete disorder.
Keyword Epidemiology
Foetal growth
Anxiety
Depression
Open Access Mandate Compliance No - Author Post-Print Requested
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 4 October 2012.

 
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Created: Fri, 12 Oct 2012, 22:24:59 EST by James Scott on behalf of Psychiatry - Royal Brisbane and Women's Hospital