The Small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster

Hedges, Lauren M., Yamada, Ryuichi, O'Neill, Scott L. and Johnson, Karyn N. (2012) The Small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster. Applied and Environmental Microbiology, 78 18: 6773-6776. doi:10.1128/AEM.01650-12

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Author Hedges, Lauren M.
Yamada, Ryuichi
O'Neill, Scott L.
Johnson, Karyn N.
Title The Small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster
Formatted title
The small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster
Journal name Applied and Environmental Microbiology   Check publisher's open access policy
ISSN 0099-2240
1098-5336
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1128/AEM.01650-12
Open Access Status File (Publisher version)
Volume 78
Issue 18
Start page 6773
End page 6776
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2013
Language eng
Formatted abstract
Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia-mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense. Compared to Wolbachia-free flies, virus-induced mortality was delayed in Wolbachia-infected flies with loss-of-function of siRNA pathway components, indicating that Wolbachia-mediated protection functions in the absence of the canonical siRNA pathway.
Keyword Distinct roles
Host defense
Infection
Immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biological Sciences Publications
 
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Created: Fri, 12 Oct 2012, 18:37:22 EST by System User on behalf of School of Biological Sciences