A new strategy of heterosis research in mice - approach and results on chromosome 19

Brunsch, C., Philipp, U., Reinecke, P., Moser, G., Geldermann, H., Koepke, K., Leucht, W. and Stier, H. (1999) A new strategy of heterosis research in mice - approach and results on chromosome 19. Archiv Fur Tierzucht-Archives of Animal Breeding, 42 1: 103-109.

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Author Brunsch, C.
Philipp, U.
Reinecke, P.
Moser, G.
Geldermann, H.
Koepke, K.
Leucht, W.
Stier, H.
Title A new strategy of heterosis research in mice - approach and results on chromosome 19
Journal name Archiv Fur Tierzucht-Archives of Animal Breeding   Check publisher's open access policy
ISSN 0003-9438
Publication date 1999-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 42
Issue 1
Start page 103
End page 109
Total pages 7
Place of publication Dummerstorf, Germany
Publisher Forschungsinstitut fuer die Biologie Landwirtschaftlicher Nutztiere
Language eng
Formatted abstract
The following steps were performed to analyse heterosis and QTL effects in litter size of mice: intercross of mouse inbred strains C57BL/6J and Balb/cJ in order to produce a F2 generation with 948 female animals; selection of trait groups with extreme high ((13 offspring) and extreme low litter size (5 offspring)); typing of 56 microsatellites with an average distance of 32 cM; detection of different chromosome regions with associations to heterosis in litter size. Chromosome 19 was associated to heterosis in litter size. Additional animals with extreme high and low litter sizes were then typed for four DNA markers on chromosome 19 and used for QTL mapping. A QTL was identified for litter size in segment D19Mit28 - D19Mit99 with a maximum at 15 cM (p≤0.05). The QTL explains about 11 % of the phenotypic variance in the F2 generation. With a degree of dominance of 4.09 the QTL shows that superdominance can explain heterosis in litter size.
Keyword heterosis
DNA marker
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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