Uropathogenic Escherichia coli mediated urinary tract infection

Totsika, Makrina, Moriel, Danilo Gomes, Idris, Adi, Rogers, Benjamin A., Wurpel, Daniel J., Phan, Minh-Duy, Paterson, David L. and Schembri, Mark A. (2012) Uropathogenic Escherichia coli mediated urinary tract infection. Current Drug Targets, 13 11: 1386-1399. doi:10.2174/138945012803530206

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Author Totsika, Makrina
Moriel, Danilo Gomes
Idris, Adi
Rogers, Benjamin A.
Wurpel, Daniel J.
Phan, Minh-Duy
Paterson, David L.
Schembri, Mark A.
Title Uropathogenic Escherichia coli mediated urinary tract infection
Formatted title
Uropathogenic Escherichia coli mediated urinary tract infection
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
Publication date 2012-10
Sub-type Article (original research)
DOI 10.2174/138945012803530206
Volume 13
Issue 11
Start page 1386
End page 1399
Total pages 14
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Formatted abstract
Urinary tract infection (UTI) is among the most common infectious diseases of humans and is the most common nosocomial infection in the developed world. They cause significant morbidity and mortality, with approximately 150 million cases globally per year. It is estimated that 40-50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic E. coli (UPEC) is the primary cause of UTI. This review presents an overview of the primary virulence factors of UPEC, the major host responses to infection of the urinary tract, the emergence of specific multidrug resistant clones of UPEC, antibiotic treatment options for UPEC-mediated UTI and the current state of vaccine strategies as well as other novel anti-adhesive and prophylactic approaches to prevent UTI. New and emerging themes in UPEC research are also discussed in the context of future outlooks.
Keyword Antibiotic resistance
Uropathogenic Escherichia coli
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 04 Oct 2012, 11:13:39 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences