Pharmacogenomics and warfarin therapy

Martin, Jennifer and Somogyi, Andrew (2012). Pharmacogenomics and warfarin therapy. In A. Dasgupta (Ed.), Therapeutic drug monitoring: newer drugs and biomarkers (pp. 161-174) London, United Kingdom: Academic Elsevier Science. doi:10.1016/B978-0-12-385467-4.00008-7

Author Martin, Jennifer
Somogyi, Andrew
Title of chapter Pharmacogenomics and warfarin therapy
Title of book Therapeutic drug monitoring: newer drugs and biomarkers
Place of Publication London, United Kingdom
Publisher Academic Elsevier Science
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-385467-4.00008-7
ISBN 9780123854674
Editor A. Dasgupta
Chapter number 8
Start page 161
End page 174
Total pages 14
Total chapters 19
Collection year 2013
Language eng
Abstract/Summary There is a large variability in warfarin dosage requirements. While some variability is related to factors such as gender and age, a large amount intra- and inter-patient variability is not accounted for. There are algorithms of warfarin dosing, but in general such algorithms have not taken into account possible genetic factors that may contribute to pharmacokinetics and pharmacodynamics of warfarin therapy, thus eventually helping in predicting an individual's loading and maintenance doses for safer anticoagulation. This chapter discusses the factors known to affect therapeutic anticoagulation with warfarin, including the pharmacogenetic polymorphisms in CYP2C9 and genetic polymorphisms in the C1 subunit of the vitamin K 2, 3 epoxide reductase complex (VKORC1). Although pharmacogenomics testing per se is an exciting intellectual possibility, it does not predict all of the variation to be part of routine care. However, with more information about the effects of dietary components and incorporation into a model with relevant clinical factors, this knowledge could be very useful in improving the efficacy of warfarin therapy.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes eBook

Document type: Book Chapter
Collections: Official 2013 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 03 Oct 2012, 11:50:43 EST by Dr Jennifer Martin on behalf of UQ Diamantina Institute