Anion-induced reconstitution of a self-assembling system to express a chloride-binding Co(10)L(15) pentagonal prism

Riddell, Imogen A., Smulders, Maarten M. J., Clegg, Jack K., Hristova, Yana R., Breiner, Boris, Thoburn, John D. and Nitschke, Jonathan R. (2012) Anion-induced reconstitution of a self-assembling system to express a chloride-binding Co(10)L(15) pentagonal prism. Nature Chemistry, 4 9: 751-756.


Author Riddell, Imogen A.
Smulders, Maarten M. J.
Clegg, Jack K.
Hristova, Yana R.
Breiner, Boris
Thoburn, John D.
Nitschke, Jonathan R.
Title Anion-induced reconstitution of a self-assembling system to express a chloride-binding Co(10)L(15) pentagonal prism
Journal name Nature Chemistry   Check publisher's open access policy
ISSN 1755-4330
1755-4349
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1038/NCHEM.1407
Volume 4
Issue 9
Start page 751
End page 756
Total pages 6
Place of publication London, United Kingdom
Publisher Nature
Collection year 2013
Language eng
Abstract Biochemical systems are adaptable, capable of reconstitution at all levels to achieve the functions associated with life. Synthetic chemical systems are more limited in their ability to reorganize to achieve new functions; they can reconfigure to bind an added substrate (template effect) or one binding event may modulate a receptor's affinity for a second substrate (allosteric effect). Here we describe a synthetic chemical system that is capable of structural reconstitution on receipt of one anionic signal (perchlorate) to create a tight binding pocket for another anion (chloride). The complex, barrel-like structure of the chloride receptor is templated by five perchlorate anions. This second-order templation phenomenon allows chemical networks to be envisaged that express more complex responses to chemical signals than is currently feasible.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 5 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 03 Oct 2012, 09:54:45 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences