Adaptors in toll-like receptor signaling and their potential as therapeutic targets

Ve, Thomas, Gay, Nicholas J., Mansell, Ashley, Kobe, Bostjan and Kellie, Stuart (2012) Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Current Drug Targets, 13 11: 1360-1374.

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Author Ve, Thomas
Gay, Nicholas J.
Mansell, Ashley
Kobe, Bostjan
Kellie, Stuart
Title Adaptors in toll-like receptor signaling and their potential as therapeutic targets
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
1873-5592
Publication date 2012-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138945012803530260
Volume 13
Issue 11
Start page 1360
End page 1374
Total pages 15
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group. Other TIR domain-containing proteins have also been shown to regulate these signaling pathways, including ST2 and SIGIRR, as well as several bacterial and viral TIR domain-containing proteins that modulate these pathways as virulence factors. TLR pathways and the adaptor proteins are associated with a number of diseases, including infection, sepsis, inflammatory, allergic and autoimmune diseases and cancer. We review our current understanding of the structure and function of adaptor proteins and their regulatory proteins, their association with disease and their potential as therapeutic targets in human disease.
Keyword Toll-like receptors (TLRs)
TIR (Toll/interleukin-1 receptor) domain
Adaptor proteins
Nf-Kappa-B
Open Access Mandate Compliance No - Author Post-Print Requested
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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