Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium

Setiawan, Veronica Wendy, Pike, Malcolm C., Karageorgi, Stalo, Deming, Sandra L., Anderson, Kristin, Bernstein, Leslie, Brinton, Louise A., Cai, Hui, Cerhan, James R., Cozen, Wendy, Chen, Chu, Doherty, Jennifer, Freudenheim, Jo L., Goodman, Marc T., Hankinson, Susan E., Lacey, James V., Jr., Liang, Xiaolin, Lissowska, Jolanta, Lu, Lingeng, Lurie, Galina, Mack, Thomas, Matsuno, Rayna K., McCann, Susan, Moysich, Kirsten B., Olson, Sara H., Rastogi, Radhai, Rebbeck, Timothy R., Risch, Harvey, Robien, Kim, Schairer, Catherine, Shu, Xiao-Ou, Spurdle, Amanda B., Strom, Brian L., Thompson, Pamela J., Ursin, Giske, Webb, Penelope M., Weiss, Noel S., Wentzensen, Nicolas, Xiang, Yong-Bing, Yang, Hannah P., Yu, Herbert, Horn-Ross, Pamela L., De Vivo, Immaculata and and the Australian National Endometrial Cancer Study Group (2012) Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium. American Journal of Epidemiology, 176 4: 269-278. doi:10.1093/aje/kws129

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Author Setiawan, Veronica Wendy
Pike, Malcolm C.
Karageorgi, Stalo
Deming, Sandra L.
Anderson, Kristin
Bernstein, Leslie
Brinton, Louise A.
Cai, Hui
Cerhan, James R.
Cozen, Wendy
Chen, Chu
Doherty, Jennifer
Freudenheim, Jo L.
Goodman, Marc T.
Hankinson, Susan E.
Lacey, James V., Jr.
Liang, Xiaolin
Lissowska, Jolanta
Lu, Lingeng
Lurie, Galina
Mack, Thomas
Matsuno, Rayna K.
McCann, Susan
Moysich, Kirsten B.
Olson, Sara H.
Rastogi, Radhai
Rebbeck, Timothy R.
Risch, Harvey
Robien, Kim
Schairer, Catherine
Shu, Xiao-Ou
Spurdle, Amanda B.
Strom, Brian L.
Thompson, Pamela J.
Ursin, Giske
Webb, Penelope M.
Weiss, Noel S.
Wentzensen, Nicolas
Xiang, Yong-Bing
Yang, Hannah P.
Yu, Herbert
Horn-Ross, Pamela L.
De Vivo, Immaculata
and the Australian National Endometrial Cancer Study Group
Total Author Count Override 98
Title Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium
Journal name American Journal of Epidemiology   Check publisher's open access policy
ISSN 0002-9262
1476-6256
Publication date 2012-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/aje/kws129
Volume 176
Issue 4
Start page 269
End page 278
Total pages 10
Place of publication Oxford, England, U.K.
Publisher Oxford University Press
Collection year 2013
Language eng
Formatted abstract Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (Ptrend < 0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95% confidence interval: 0.85, 0.90). Women who last gave birth at 40 years of age or older had a 44% decreased risk compared with women who had their last birth under the age of 25 years (95% confidence interval: 47, 66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years.
Keyword Endometrial neoplasms
Parity
Reproductive history
Reproductive factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Population Health Publications
School of Medicine Publications
 
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Created: Tue, 25 Sep 2012, 16:08:11 EST by Matthew Lamb on behalf of School of Medicine