The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers

Laitman, Yael, Kuchenbaecker, Karoline B., Rantala, Johanna, Hogervorst, Frans, Peock, Susan, Godwin, Andrew K., Arason, Adalgeir, Kirchhoff, Tomas, Offit, Kenneth, Isaacs, Claudine, Schmutzler, Rita K., Wappenschmidt, Barbara, Nevanlinna, Heli, Chen, Xiaoqing, Chenevix-Trench, Georgia, Healey, Sue, Couch, Fergus, Peterlongo, Paolo, Radice, Paolo, Nathanson, Katherine L., Caligo, Maria Adelaide, Neuhausen, Susan L., Ganz, Patricia, Sinilnikova, Olga M., McGuffog, Lesley, Easton, Douglas F., Antoniou, Antonis C., Wolf, Ido and Friedman, Eitan (2012) The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment, 132 3: 1119-1126. doi:10.1007/s10549-011-1938-8

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Author Laitman, Yael
Kuchenbaecker, Karoline B.
Rantala, Johanna
Hogervorst, Frans
Peock, Susan
Godwin, Andrew K.
Arason, Adalgeir
Kirchhoff, Tomas
Offit, Kenneth
Isaacs, Claudine
Schmutzler, Rita K.
Wappenschmidt, Barbara
Nevanlinna, Heli
Chen, Xiaoqing
Chenevix-Trench, Georgia
Healey, Sue
Couch, Fergus
Peterlongo, Paolo
Radice, Paolo
Nathanson, Katherine L.
Caligo, Maria Adelaide
Neuhausen, Susan L.
Ganz, Patricia
Sinilnikova, Olga M.
McGuffog, Lesley
Easton, Douglas F.
Antoniou, Antonis C.
Wolf, Ido
Friedman, Eitan
Title The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers
Journal name Breast Cancer Research and Treatment   Check publisher's open access policy
ISSN 0167-6806
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1007/s10549-011-1938-8
Open Access Status
Volume 132
Issue 3
Start page 1119
End page 1126
Total pages 8
Place of publication New York, NY, U.S.A.
Publisher Springer New York LLC
Collection year 2013
Language eng
Formatted abstract
Klotho (KL) is a putative tumor suppressor gene in breast and pancreatic cancers located at chromosome 13q12. A functional sequence variant of Klotho (KL-VS) was previously reported to modify breast cancer risk in Jewish BRCA1 mutation carriers. The effect of this variant on breast and ovarian cancer risks in non-Jewish BRCA1/BRCA2 mutation carriers has not been reported. The KL-VS variant was genotyped in women of European ancestry carrying a BRCA mutation: 5,741 BRCA1 mutation carriers (2,997 with breast cancer, 705 with ovarian cancer, and 2,039 cancer free women) and 3,339 BRCA2 mutation carriers (1,846 with breast cancer, 207 with ovarian cancer, and 1,286 cancer free women) from 16 centers. Genotyping was accomplished using TaqMan® allelic discrimination or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Data were analyzed within a retrospective cohort approach, stratified by country of origin and Ashkenazi Jewish origin. The per-allele hazard ratio (HR) for breast cancer was 1.02 (95% CI 0.93–1.12, P = 0.66) for BRCA1 mutation carriers and 0.92 (95% CI 0.82–1.04, P = 0.17) for BRCA2 mutation carriers. Results remained unaltered when analysis excluded prevalent breast cancer cases. Similarly, the per-allele HR for ovarian cancer was 1.01 (95% CI 0.84–1.20, P = 0.95) for BRCA1 mutation carriers and 0.9 (95% CI 0.66–1.22, P = 0.45) for BRCA2 mutation carriers. The risk did not change when carriers of the 6174delT mutation were excluded. There was a lack of association of the KL-VS Klotho variant with either breast or ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Keyword Breast cancer
Ovarian cancer-Klotho
Modifier gene
Genetic Susceptibility
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 25 Sep 2012, 11:26:57 EST by Matthew Lamb on behalf of School of Medicine