Insulin analogues: reviewing the pros and cons in managing diabetes mellitus

Martin, Jennifer H., Russell, Anthony, O'Moore-Sullivan, Trisha and Prins, Johannes B. (2011) Insulin analogues: reviewing the pros and cons in managing diabetes mellitus. Journal of Pharmacogenomics and Pharmacoproteomics, 2 3: . doi:10.4172/2153-0645.1000106

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Author Martin, Jennifer H.
Russell, Anthony
O'Moore-Sullivan, Trisha
Prins, Johannes B.
Title Insulin analogues: reviewing the pros and cons in managing diabetes mellitus
Journal name Journal of Pharmacogenomics and Pharmacoproteomics   Check publisher's open access policy
ISSN 2153-0645
Publication date 2011
Year available 2011
Sub-type Article (original research)
DOI 10.4172/2153-0645.1000106
Open Access Status File (Publisher version)
Volume 2
Issue 3
Total pages 5
Place of publication Los Angeles, CA United States
Publisher Omics Publishing Group
Collection year 2012
Language eng
Formatted abstract
The issue of planning the timing and dosing of insulin in relation to food is one of the most difficult issues confronting people with diabetes. Recent focus on improving quality of life in this area has focused on developing different modes of administration of insulin thereby avoiding subcutaneous injections and developing new analogues
of insulin. Both inhalational and buccal administration technologies have been developed, and have essentially overcome some of the difficult pharmacokinetic issues regarding large peptide molecules, however there remain some clinical problems. Advances in the practicalities of treating insulin have occurred, such as more accurate and less expensive glucometers, new administration alternatives such as implantable pumps, with further developments in the pipeline including islet and gene replacement for Type I disease. However all of these newer options have
limitations and currently subcutaneous administration is the only real option for most people. Insulin analogues have so far been relatively disappointing in terms of improvement in mortality and morbidity although for some patients the ability to alter the dosage of insulin depending on the planned meal size or reduction of between meal snacks has been helpful. Furthermore there is a yet unknown question around long term safety. This review will discuss the major clinical issues surrounding the new insulin analogues as they relate to efficacy and side effects.
Keyword Insulin
Recombinant
Methods of delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Received November 20, 2010; Accepted December 21, 2011; Published December 23, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 24 Sep 2012, 17:33:06 EST by Dr Anthony Russell on behalf of Medicine - Princess Alexandra Hospital