Wide-field Assessment of the Human Corneal Subbasal Nerve Plexus in Diabetic Neuropathy Using Novel Mapping Technique

Edwards, Kathe, Pritchard, Nicola, Gosschalk, Kevin, Sampson, Geoff P., Russell, Anthony, Malik, Rayaz A. and Efron, Nathan (2012) Wide-field Assessment of the Human Corneal Subbasal Nerve Plexus in Diabetic Neuropathy Using Novel Mapping Technique. Cornea, 31 9: 1078-1082.


Author Edwards, Kathe
Pritchard, Nicola
Gosschalk, Kevin
Sampson, Geoff P.
Russell, Anthony
Malik, Rayaz A.
Efron, Nathan
Title Wide-field Assessment of the Human Corneal Subbasal Nerve Plexus in Diabetic Neuropathy Using Novel Mapping Technique
Journal name Cornea   Check publisher's open access policy
ISSN 0277-3740
1536-4798
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1097/ICO.0b013e318245c012
Volume 31
Issue 9
Start page 1078
End page 1082
Total pages 5
Place of publication Philadelphia, United States
Publisher Lippincott Williams and Wilkins
Collection year 2013
Language eng
Formatted abstract To develop a rapid optimized technique of wide-field imaging of the human corneal subbasal nerve plexus. A dynamic fixation target was developed and, coupled with semiautomated tiling software, a rapid method of capturing and montaging multiple corneal confocal microscopy images was created. To illustrate the utility of this technique, wide-field maps of the subbasal nerve plexus were produced in 2 participants with diabetes, 1 with and 1 without neuropathy. The technique produced montages of the central 3 mm of the subbasal corneal nerve plexus. The maps seem to show a general reduction in the number of nerve fibers and branches in the diabetic participant with neuropathy compared with the individual without neuropathy. This novel technique will allow more routine and widespread use of subbasal nerve plexus mapping in clinical and research situations. The significant reduction in the time to image the corneal subbasal nerve plexus should expedite studies of larger groups of diabetic patients and those with other conditions affecting nerve fibers. The inferior whorl and the surrounding areas may show the greatest loss of nerve fibers in individuals with diabetic neuropathy, but this should be further investigated in a larger cohort.
Keyword Cornea
Corneal nerves
Diabetes
Diabetic neuropathy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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Created: Mon, 24 Sep 2012, 17:14:34 EST by Dr Anthony Russell on behalf of Medicine - Princess Alexandra Hospital