Magnetised thermo responsive lipid vehicles for targeted and controlled lung drug delivery

Upadhyay, Dhrumil, Scalia, Santo, Vogel, Robert, Wheate, Nial, Salama, Rania O., Young, Paul M., Traini, Daniela and Chrzanowski, Wojciech (2012) Magnetised thermo responsive lipid vehicles for targeted and controlled lung drug delivery. Pharmaceutical Research, 29 9: 2456-2467. doi:10.1007/s11095-012-0774-9

Author Upadhyay, Dhrumil
Scalia, Santo
Vogel, Robert
Wheate, Nial
Salama, Rania O.
Young, Paul M.
Traini, Daniela
Chrzanowski, Wojciech
Title Magnetised thermo responsive lipid vehicles for targeted and controlled lung drug delivery
Journal name Pharmaceutical Research   Check publisher's open access policy
ISSN 0724-8741
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1007/s11095-012-0774-9
Open Access Status
Volume 29
Issue 9
Start page 2456
End page 2467
Total pages 12
Place of publication New York, NY, United States
Publisher Springer
Collection year 2013
Language eng
Formatted abstract
Purpose: Conditions such as lung cancer currently lack non-invasively targetable and controlled release topical inhalational therapies. Superparamagnetic iron-oxide nanoparticles (SPIONs) have shown promising results as a targetable therapy. We aimed to fabricate and test the in-vitro performance of particles with SPION and drug within a lipid matrix as a potentially targetable and thermo-sensitive inhalable drug-delivery system.

Methods: Budesonide and SPIONs were incorporated into lipid particles using oil-in-water emulsification. Particles size, chemical composition, responsiveness to magnetic field, thermosensitiveness and inhalation performance in-vitro were investigated.

Results: Particles of average diameter 2-4 μm with budesonide and SPIONs inside the lipid matrix responded to a magnetic field with 100% extraction at a distance of 5 mm. Formulations were shown to have accelerated rate of drug release at hyperthermic temperatures (45°C)-controlled release. The produced inhalation dry powder presented promising inhalation performance, with an inhalable fine particle fraction of 30%.

Conclusions: The lipid system presented thermo-sensitive characteristics, suitable for controlled delivery, the model drug and SPION loaded lipid system was magnetically active and movable using simple permanent magnets, and the system demonstrates promise as an effective drug vehicle in targeted and controlled inhalation therapy.
Keyword Controlled drug delivery
Iron oxide
Triggered drug release
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 15 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2013 Collection
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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