Flowability of binary mixtures of commercial and reprocessed ibuprofen through high shear wet milling (HSWM) with lactose

Liu, L. X., Rashid, A., Marziano, I., White, E. T., Howes, T. and Litster, J. D. (2012) Flowability of binary mixtures of commercial and reprocessed ibuprofen through high shear wet milling (HSWM) with lactose. Advanced Powder Technology, 23 4: 454-458. doi:10.1016/j.apt.2012.03.006


Author Liu, L. X.
Rashid, A.
Marziano, I.
White, E. T.
Howes, T.
Litster, J. D.
Title Flowability of binary mixtures of commercial and reprocessed ibuprofen through high shear wet milling (HSWM) with lactose
Journal name Advanced Powder Technology   Check publisher's open access policy
ISSN 0921-8831
1568-5527
Publication date 2012-07
Sub-type Article (original research)
DOI 10.1016/j.apt.2012.03.006
Open Access Status
Volume 23
Issue 4
Start page 454
End page 458
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
This study investigates the flow properties of binary mixtures of both commercial ibuprofen and reprocessed ibuprofen through high shear milling with lactose powders. Ibuprofen is recrystallized in a 30% water–ethanol mixture before high shear wet milling (HSWM). In-situ Process Analytical Techniques (PAT) (Labmax®) is used to study the HSWM process dynamics, with particle size measured by a Lasentec Focused Beam Reflectance Measurement, FBRM®. The flow properties of the binary mixtures of the different ibuprofen particles and its binary mixtures with lactose were measured using a Schulze® RST-XS ring shear tester. Results show that the morphology of ibuprofen was changed from needle to hexagonal like crystals during recrystallization and crystal size was reduced dramatically by HSWM for 1 h. The flowability of milled ibuprofen powders is reduced significantly due to its reduced size and change of surface morphology. Mixing the HSWM ibuprofen powders with lactose enhanced its flow properties. However, the increase of the mixture flowability for HSWM ibuprofen is less significant in comparison to the binary mixtures of lactose with commercial ibuprofen.
Keyword Ibuprofen
High shear wet milling
Flowability
Binary mixtures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue Featuring Articles from Chemeca 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
Official 2013 Collection
 
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