Transient regenerative potential of the neonatal mouse heart

Porrello, Enzo R., Mahmoud, Ahmed I., Simpson, Emma, Hill, Joseph A., Richardson, James A., Olson, Eric N. and Sadek, Hesham A. (2011) Transient regenerative potential of the neonatal mouse heart. Science, 331 6020: 1078-1080. doi:10.1126/science.1200708

Author Porrello, Enzo R.
Mahmoud, Ahmed I.
Simpson, Emma
Hill, Joseph A.
Richardson, James A.
Olson, Eric N.
Sadek, Hesham A.
Title Transient regenerative potential of the neonatal mouse heart
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2011-02-25
Sub-type Article (original research)
DOI 10.1126/science.1200708
Volume 331
Issue 6020
Start page 1078
End page 1080
Total pages 3
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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