Estimating heritability from twin studies

Verweij, Karin J. H., Mosing, Miriam A., Zietsch, Brendan P. and Medland, Sarah E. (2012). Estimating heritability from twin studies. In Robert C. Elston, Jaya M. Satagopan and Shuying Sun (Ed.), Statistical human genetics: methods and protocols (pp. 151-170) New York, United States: Humana Press. doi:10.1007/978-1-61779-555-8_9


Author Verweij, Karin J. H.
Mosing, Miriam A.
Zietsch, Brendan P.
Medland, Sarah E.
Title of chapter Estimating heritability from twin studies
Title of book Statistical human genetics: methods and protocols
Place of Publication New York, United States
Publisher Humana Press
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-61779-555-8_9
Series Methods in Molecular Biology
ISBN 9781617795541
ISSN 1064-3745
Editor Robert C. Elston
Jaya M. Satagopan
Shuying Sun
Volume number 850
Chapter number 9
Start page 151
End page 170
Total pages 20
Total chapters 30
Collection year 2013
Language eng
Abstract/Summary This chapter describes how the heritability of a trait can be estimated using data collected from pairs of twins. The principles of the classical twin design are described, followed by the assumptions and possible extensions of the design. In the second part of this chapter, two example scripts are presented and described, explaining the basic steps for estimating heritability using the statistical program OpenMx. OpenMx and the scripts used for this chapter can be downloaded so that readers can adapt and use the scripts for their own purposes.
Keyword Heritability
Behavior genetics
Twin
Mx
OpenMx
Quantitative genetics
Twinmodeling
Classical twin design
Genetics
Environment
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
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Created: Fri, 21 Sep 2012, 09:59:35 EST by Ms Ramona Hooyer on behalf of School of Psychology