Morphine and metastasis: from bench to bedside

Parat, Marie-Odile (2013). Morphine and metastasis: from bench to bedside. In Marie-Odile Para (Ed.), Morphine and metastasis (pp. 1-13) Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-5678-6_1

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Author Parat, Marie-Odile
Title of chapter Morphine and metastasis: from bench to bedside
Title of book Morphine and metastasis
Place of Publication Dordrecht, Netherlands
Publisher Springer
Publication Year 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-94-007-5678-6_1
Open Access Status
ISBN 9789400756779
9400756771
9789400756786
Editor Marie-Odile Para
Chapter number 1
Start page 1
End page 13
Total pages 13
Total chapters 9
Collection year 2014
Language eng
Abstract/Summary The possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. Future directions in the field may include the role of endogenous morphine in tumour biology, the recent discovery that genetic polymorphisms of the mu opioid receptor are associated with cancer survival, the role of microRNAs in opioid receptor regulation and signalling, and the potential usefulness of peripheral opioid antagonists.
Keyword Cancer
Endogenous morphine
Immunosuppression
Methylnaltrexone
MicroRNA
Morphine glucuronides
Opioid antagonists
Opioid receptor
Pain management
Polymorphism
Surgery
Tolerance
Tumor microenvironment
Withdrawal
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Official 2014 Collection
School of Pharmacy Publications
 
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Created: Thu, 20 Sep 2012, 16:16:38 EST by Myrtle Sahabandu on behalf of School of Pharmacy