Iron and liver disease

Crawford, Darrell H. G., Fletcher, Linda M. and Kowdley, Kris V. (2012). Iron and liver disease. In Gregory J. Anderson and Gordon D. McLaren (Ed.), Iron physiology and pathophysiology in humans (pp. 441-445) New York, United States: Humana Press. doi:10.1007/978-1-60327-485-2_22


Author Crawford, Darrell H. G.
Fletcher, Linda M.
Kowdley, Kris V.
Title of chapter Iron and liver disease
Title of book Iron physiology and pathophysiology in humans
Place of Publication New York, United States
Publisher Humana Press
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-60327-485-2_22
Series Nutrition and Health
ISBN 9781603274845
1603274847
9781603274852
1603274855
Editor Gregory J. Anderson
Gordon D. McLaren
Chapter number 22
Start page 441
End page 445
Total pages 5
Total chapters 31
Collection year 2013
Language eng
Abstract/Summary Altered iron metabolism, as demonstrated by the presence of increased hepatic iron stores and elevated serum ferritin concentration, is a relatively common feature of various liver diseases, including hepatitis C virus infection, nonalcoholic fatty liver disease, and alcoholic liver injury. Hepatic siderosis is also present in a significant proportion of patients with end-stage liver disease. The pathophysiological basis of excess hepatic iron in these conditions is increasingly understood and relates to changes in hepcidin synthesis, altered expression of intestinal iron transporters and increased intestinal iron absorption, as well as hepatic necroinflammation with a concomitant cellular redistribution of liver iron stores. There is evidence in many of these conditions that the presence of excess iron adversely affects the natural history of liver diseases and contributes to an acceleration of disease progression and a higher rate of adverse clinical events, as well as increased mortality before and after liver transplantation. Despite this emerging evidence, therapeutic strategies designed to normalize iron indices in these conditions are not widely practiced and remain a potential area for further investigation.
Keyword Alcohol
Cirrhosis
Hepatitis C virus
Hepcidin
Iron
Steatosis
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Part 4

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Created: Wed, 19 Sep 2012, 15:09:43 EST by Ms Ramona Hooyer on behalf of School of Medicine