Frequency-selective rotation of two-particle nanoactuators for rapid and sensitive detection of biomolecules

Ranzoni, Andrea, Schleipen, Jean J. H. B., van Ijzendoorn, Leo J. and Prins, Menno W. J. (2011) Frequency-selective rotation of two-particle nanoactuators for rapid and sensitive detection of biomolecules. Nano Letters, 11 5: 2017-2022. doi:10.1021/nl200384p


Author Ranzoni, Andrea
Schleipen, Jean J. H. B.
van Ijzendoorn, Leo J.
Prins, Menno W. J.
Title Frequency-selective rotation of two-particle nanoactuators for rapid and sensitive detection of biomolecules
Journal name Nano Letters   Check publisher's open access policy
ISSN 1530-6984
1530-6992
Publication date 2011-05
Sub-type Article (original research)
DOI 10.1021/nl200384p
Volume 11
Issue 5
Start page 2017
End page 2022
Total pages 6
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract We describe an optomagnetic bionanotechnology for rapidand sensitive solution-based affinity assays. Nanoactuators made from bioactive magnetic nanoparticles undergo rotational motion in the volume of a fluid under frequency-controlled magnetic actuation. The nanoactuators show a time-dependent scattering cross-section to an incoming light beam. We demonstrate that the temporal behavior of the scattered light intensity relates to the number, the magnetic properties and the size distribution of the nanoactuators, independently revealing the average value and variation in the magnetic properties of the nanoparticles as well as the concentration of nanoactuators. The method is applied to detect biomolecules in fluid by interparticle binding. In a total assay time of less than 3 min, we demonstrate a limit of detection lower than 400 fM in buffer and 5 pM in human plasma.
Keyword Magnetic nanoparticle
Rotation
Optical scattering
Cluster
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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