Population biological principles of drug-resistance evolution in infectious diseases

zur Wiesch, Pia Abel, Kouyos, Roger, Engelstaedter, Jan, Regoes, Roland R. and Bonhoeffer, Sebastian (2011) Population biological principles of drug-resistance evolution in infectious diseases. Lancet Infectious Diseases, 11 3: 236-247. doi:10.1016/S1473-3099(10)70264-4


Author zur Wiesch, Pia Abel
Kouyos, Roger
Engelstaedter, Jan
Regoes, Roland R.
Bonhoeffer, Sebastian
Title Population biological principles of drug-resistance evolution in infectious diseases
Journal name Lancet Infectious Diseases   Check publisher's open access policy
ISSN 1473-3099
1474-4457
Publication date 2011-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1473-3099(10)70264-4
Volume 11
Issue 3
Start page 236
End page 247
Total pages 12
Place of publication London, United Kingdom
Publisher The Lancet Publishing Group
Language eng
Abstract The emergence of resistant pathogens in response to selection pressure by drugs and their possible disappearance when drug use is discontinued are evolutionary processes common to many pathogens. Population biological models have been used to study the dynamics of resistance in viruses, bacteria, and eukaryotic microparasites both at the level of the individual treated host and of the treated host population. Despite the existence of generic features that underlie such evolutionary dynamics, different conclusions have been reached about the key factors affecting the rate of resistance evolution and how to best use drugs to minimise the risk of generating high levels of resistance. Improved understanding of generic versus specific population biological aspects will help to translate results between different studies, and allow development of a more rational basis for sustainable drug use than exists at present.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biological Sciences Publications
 
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