Haemodynamic modeling of the cardiovascular system using mock circulation loops to test cardiovascular devices

Timms, Daniel L., Gregory, Shaun D., Stevens, Michael C. and Fraser, John F. (2011). Haemodynamic modeling of the cardiovascular system using mock circulation loops to test cardiovascular devices. In: Proceedings of the 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Boston, MA, United States, (4301-4304). 30 August - 3 September 2011. doi:10.1109/IEMBS.2011.6091068


Author Timms, Daniel L.
Gregory, Shaun D.
Stevens, Michael C.
Fraser, John F.
Title of paper Haemodynamic modeling of the cardiovascular system using mock circulation loops to test cardiovascular devices
Conference name 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS)
Conference location Boston, MA, United States
Conference dates 30 August - 3 September 2011
Proceedings title Proceedings of the 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society   Check publisher's open access policy
Journal name Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   Check publisher's open access policy
Place of Publication Piscataway, NJ, United States
Publisher IEEE
Publication Year 2011
Sub-type Fully published paper
DOI 10.1109/IEMBS.2011.6091068
ISBN 9781424441228
ISSN 1557-170X
Start page 4301
End page 4304
Total pages 4
Language eng
Abstract/Summary Comprehensive testing and evaluation of cardiovascular device function and performance is required prior to clinical implementation. Initial proof of concept investigations are conducted within in-vitro mock circulation loops, before proof of principle is demonstrated via in-vivo animal testing. To facilitate the rapid transition of cardiovascular devices through this development period, a testing apparatus was developed that closely models the natural human cardiovascular system haemodynamics. This mock circulation system accurately replicates cardiac function, coupled to systemic and pulmonary circulations. The physiological response produced by a number of clinical cardiovascular conditions can be actively controlled by variable parameters such as vascular resistance, arterial/venous compliance, ventricle contractility, heart rate, and heart /vascular volumes, while anatomical variations such as valve regurgitation and septal defects can be included. Auto-regulation of these parameters was attempted to reproduce the Frank-Starling mechanism, baroreceptor reflex, skeletal muscle pump, and postural changes. Steady state validation of loop performance was achieved by replicating the progression of a patient's clinical haemodynamics from heart failure, through VAD support, to heart transplantation. The system has been used to evaluate pulsatile and non-pulsatile ventricular assist devices, counter pulsation devices, non-invasive cardiac output monitors and cardiovascular stents. The interaction of these devices with the cardiovascular system was also investigated with regards to physiological control strategies and cannula placement. The system is a valuable tool for the accelerated progression of cardiovascular device development.
Keyword Ventricular Assist Device
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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