Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells

Taing, Meng-Wong, Pierson, Jean-Thomas, Hoang, Van L. T., Shaw, Paul N., Dietzgen, Ralf G., Gidley, Michael J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012) Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells. Food and Function, 3 8: 828-836. doi:10.1039/c2fo30073g


Author Taing, Meng-Wong
Pierson, Jean-Thomas
Hoang, Van L. T.
Shaw, Paul N.
Dietzgen, Ralf G.
Gidley, Michael J.
Roberts-Thomson, Sarah J.
Monteith, Gregory R.
Title Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells
Journal name Food and Function   Check publisher's open access policy
ISSN 2042-6496
2042-650X
Publication date 2012-08
Sub-type Article (original research)
DOI 10.1039/c2fo30073g
Open Access Status Not Open Access
Volume 3
Issue 8
Start page 828
End page 836
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2013
Language eng
Formatted abstract
Obesity is associated with many chronic disease states, such as diabetes mellitus, coronary disease and certain cancers, including those of the breast and colon. There is a growing body of evidence that links phytochemicals with the inhibition of adipogenesis and protection against obesity. Mangoes (Mangifera indica L.) are tropical fruits that are rich in a diverse array of bioactive phytochemicals. In this study, methanol extracts of peel and flesh from three archetypal mango cultivars; Irwin, Nam Doc Mai and Kensington Pride, were assessed for their effects on a 3T3-L1 pre-adipocyte cell line model of adipogenesis. High content imaging was used to assess: lipid droplets per cell, lipid droplet area per cell, lipid droplet integrated intensity, nuclei count and nuclear area per cell. Mango flesh extracts from the three cultivars did not inhibit adipogenesis; peel extracts from both Irwin and Nam Doc Mai, however, did so with the Nam Doc Mai extract most potent at inhibiting adipogenesis. Peel extract from Kensington Pride promoted adipogenesis. The inhibition of adipogenesis by Irwin (100 μg mL−1) and Nam Doc Mai peel extracts (50 and 100 μg mL−1) was associated with an increase in the average nuclear area per cell; similar effects were seen with resveratrol, suggesting that these extracts may act through pathways similar to resveratrol. These results suggest that differences in the phytochemical composition between mango cultivars may influence their effectiveness in inhibiting adipogenesis, and points to mango fruit peel as a potential source of nutraceuticals.
Keyword Adipogenesis
Cell lines
Chronic disease
Coronary disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2013 Collection
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 05 Sep 2012, 14:17:38 EST by Associate Professor Ralf Dietzgen on behalf of School of Pharmacy